H2N2V1, Main, Exploration, bibRecord, 001B03

In vitro anti-influenza virus activity of a plant preparation from Geranium sanguineum L.

Identifieur interne : 001B03 ( Main/Exploration ); précédent : 001B02; suivant : 001B04

In vitro anti-influenza virus activity of a plant preparation from Geranium sanguineum L.

Auteurs : Julia Serkedjieva [Bulgarie] ; Alan J. Hay [Royaume-Uni]

Source :

Antiviral Research [ 0166-3542 ] ; 1998.

RBID : ISTEX:7570466A40810550C43608B9024D67BB58584C20

English descriptors

KwdEn :
- Influenza virus, Inhibition, Plant preparation.
Teeft :
- Addition studies, Adsorption, Anti6iral, Anti6iral research, Antiviral, Antiviral action, Antiviral activity, Assay, Avian viruses, Basic life, Biological activity, Bulgarian, Bulgarian academy, Caffeic acid, Calf serum, Cell control, Cell culture, Cell monolayers, Cell viability, Comptes rendus bulg, Corresponding virus strains, Culture medium, Early stage, Effective concentration, Elisa, Elsevier science, Equal volume, Experimental infection, Geranium, Geranium sanguineum, Immunosorbent assay, Independent experiments, Individual compounds, Infectious titres, Infectious virus, Infectivity, Inhibitory, Inhibitory concentrations, Inhibitory effect, Ivancheva, Macromolecular synthesis, Manolova, Mdck, Mdck cells, Mill hill, Molecular basis, Monolayers, Optical densities, Optical density values, Parent virus, Phenolic acids, Plant origin, Plant polyphenolic, Plant preparation, Plaque, Plaque assay, Plaque formation, Plastic plates, Polyphenol compounds, Polyphenolic, Protective effect, Replication, Resistant plaques, Rimantadine, Rimantadine hydrochloride, Room temperature, Sanguineum, Scutelaria baicalensis, Selectivity, Selectivity index, Serkedjie6a, Serkedjieva, Single cycle, Thin layer chromatography, Titre, Total protein, Vanden berghe, Viral, Viral particles, Virus, Virus activity, Virus control, Virus infection, Virus infectivity, Virus proteins, Virus replication, Virus sialidase.

Abstract

Abstract: A polyphenolic complex (PC), isolated from the Bulgarian medicinal plant Geranium sanguineum L., was shown to have selective anti-influenza activity in vitro. Expression of HA on the surface of cells infected with A/chicken/Rostock/34, virus-induced cytopathic effect, infectious virus yield and plaque formation were all reduced at non-toxic concentrations of PC. Synthesis of virus proteins was also selectively inhibited. High concentrations of PC (>200 μg/ml) exhibited a strong virucidal effect. Although the action was directed against an early stage of infection (within 3 h of infection), the process directly affected was not identified. The selectivity of antiviral action was confirmed by the variation in sensitivity of different influenza viruses to PC and the selection of variants with reduced drug sensitivity.

Url:

https://api.istex.fr/ark:/67375/6H6-J3MFKVC7-Q/fulltext.pdf

DOI: 10.1016/S0166-3542(97)00067-3

Affiliations:

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Le document en format XML

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<term>Calf serum</term>
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<term>Comptes rendus bulg</term>
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<term>Effective concentration</term>
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<term>Elsevier science</term>
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<term>Room temperature</term>
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<term>Selectivity index</term>
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<term>Serkedjieva</term>
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<front><div type="abstract" xml:lang="en">Abstract: A polyphenolic complex (PC), isolated from the Bulgarian medicinal plant Geranium sanguineum L., was shown to have selective anti-influenza activity in vitro. Expression of HA on the surface of cells infected with A/chicken/Rostock/34, virus-induced cytopathic effect, infectious virus yield and plaque formation were all reduced at non-toxic concentrations of PC. Synthesis of virus proteins was also selectively inhibited. High concentrations of PC (>200 μg/ml) exhibited a strong virucidal effect. Although the action was directed against an early stage of infection (within 3 h of infection), the process directly affected was not identified. The selectivity of antiviral action was confirmed by the variation in sensitivity of different influenza viruses to PC and the selection of variants with reduced drug sensitivity.</div>
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In vitro anti-influenza virus activity of a plant preparation from Geranium sanguineum L.

In vitro anti-influenza virus activity of a plant preparation from Geranium sanguineum L.

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri